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Title Overall Utilization of Postnatal Corticosteroids During Hospitalization in Extremely Preterm Infants Born in Korea: Data from the Korean Neonatal Network
Author Ga Won Jeon
작성자 전가원
Background Dexamethasone facilitates weaning from respiratory support and reduces the risk of bronchopulmonary dysplasia (BPD), a major cause of mortality and neurodevelopmental impairment (NDI) in preterm infants, leading to increased use of postnatal corticosteroids. As survival among extremely preterm infants (EPIs) has improved, the use of corticosteroid has increased. However, concerns remain regarding adverse neurodevelopmental effects.
Aim / Hypothesis Aim: Few studies have investigated postnatal corticosteroid use during hospitalization in EPIs across different gestational age groups born in Korea and its association with outcomes according to corticosteroid exposure. This study aimed to evaluate patterns of postnatal corticosteroid use in relation to BPD incidence and determine whether corticosteroid type, and route of administration are associated with long-term growth and neurodevelopmental outcomes at corrected ages of 18–24 months and 3 years. Hypothesis: EPIs with lower gestational ages are more likely to be exposed to postnatal corticosteroids. Poor growth and neurodevelopmental outcomes in infants with lower gestational ages are associated not only with lower gestational age itself but also with postnatal corticosteroid exposure and other prematurity-related morbidities.
Inclusion Criteria Gestational age 23-31weeks
Exclusion Criteria Chromosomal abnormalities, major congenital anomalies
Study Design Statistical methods Comparison of postnatal corticosteroid use by gestational age group (23–27 vs. 28–31 weeks) Outcomes associated with postnatal corticosteroid exposure versus no exposure. Outcomes associated with postnatal corticosteroid exposure versus no exposure across different birth periods. Outcomes associated with postnatal corticosteroid exposure versus no exposure across different gestational age groups.
Primary Outcomes Postnatal corticosteroid use (frequency and type) by gestational age and birth period, Temporal changes in postnatal corticosteroid use in relation to BPD incidence trends in EPIs born in Korea
Secondary Outcomes and Definitions Death, NDI, composite outcome of NDI or death, blindness; hearing loss; cerebral palsy, failure to catch-up growth at a corrected age of 18–24 months and 3years.
Protocols Prospective study
Funding None

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