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Title Gender differences in morbidity and neurologic outcomes of very low birth weight preterm infants : stratified by gestational age
Author 양주연, 심소연
작성자 심소연
Background Very low birth weight(VLBW) preterm infants are associated with increased major neonatal morbidities and poor neurologic outcomes. Gestational age(GA) of the infant is a major risk factor for the poor outcomes of VLBW preterm infants as poor outcomes are more prevalent in earlier gestations. Also male sex has been identified as a risk factor for morbidities and developmental delay in previous studies.
Aim / Hypothesis 1) Aim The aim of the study is to investigate the difference of major neonatal morbidities and neurologic outcomes according to gender in VLBW preterm infants. The gender groups will be stratified further by gestational age (below 27+6 weeks of gestation and from 28 to 31+6 weeks of gestation) to investigate whether the differences due to gender are altered by the gestational age of the infants. 2) Hypothesis Major neonatal morbidities and neurologic outcome of VLBW preterm infants are affected by both gender and gestational age.
Inclusion Criteria VLBW (birth weight <1,500 gram) infants with GA <32 weeks registered in Korean Neonatal Network(KNN).
Exclusion Criteria Infants with congenital anomaly
Study Design Statistical methods 1) Study Design : Comparison of major neonatal morbidities and neurologic outcomes at 18-24 months corrected age between male and female VLBW preterm infants, further stratified by gestational age (GA <28 weeks and 28 weeks≤ GA <32 weeks) 2) Statistical Methods : statistical analyses will be performed by SPSS (t-test, chi-square test, multivariate logistic regression)
Primary Outcomes 1) Major neonatal morbidities : respiratory(RDS, BPD), cardicac(PDA, PPHN, hypotension), CNS(IVH, PVL), GI(NEC) complications, ROP, sepsis 2) Neurologic outcome at 18-24months corrected age : developmental and neurologic assessment, vision, hearing
Secondary Outcomes and Definitions Antenatal and perinatal characteristics
Protocols Retrospective case control study
Funding none

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